Mixing and Granulation
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Granulation Time in Fluidized Bed Granulators
Size enlargement of fine powders by wet granulation involves mixing of fine particles with a binder liquid to form larger wet granules and drying them by evaporation of the binder liquid to form larger dry granules. Identification of the time for completion of granulation process is critical as further mixing of dry granules is providing extra energy for their attrition. In a batch fluidized be...
متن کامل[Preparation and evaluation of taste masked orally disintegrating tablets with granules made by the wet granulation method].
Using furosemide (FU) as a model drug, we examined the wet granulation method as a way to improve the taste masking and physical characteristics of orally disintegrating tablets (ODTs). In the wet granulation method, yogurt powder (YO) was used as a corrective and maltitol (MA) was used as a binding agent. The taste masked FU tablets were prepared using the direct compression method. Microcryst...
متن کاملAspects of Screw Design for Wet Granulation Extrusion
This paper discusses our preliminary trials examining the particle size and particle shape of granules produced by different screw elements in a co-rotating twin-screw extruder. In general, conveying elements did not provide the necessary consolidation to allow large particles to grow in significant quantity, whereas the different mixing elements led to the large particles desired for tablettin...
متن کاملWet granulation in a twin-screw extruder: implications of screw design.
Wet granulation in twin-screw extrusion machinery is an attractive technology for the continuous processing of pharmaceuticals. The performance of this machinery is integrally tied to its screw design yet little fundamental knowledge exists in this emerging field for granulation to intelligently create, troubleshoot, and scale-up such processes. This study endeavored to systematically examine t...
متن کاملGranulation techniques and technologies: recent progresses
Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. Granulation process transforms fine powders into free-flowing, dust-free granules that are easy to compress. Nevertheless, granulation poses numerous challenges due to high quality requirement o...
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تاریخ انتشار 2008